The cost-effectiveness of providing a DAFNE follow-up intervention to predicted non-responders 2012
J Kruger
A Brennan
P Thokala
S Heller
10.15131/shef.data.11902053.v1
https://orda.shef.ac.uk/articles/poster/The_cost-effectiveness_of_providing_a_DAFNE_follow-up_intervention_to_predicted_non-responders_2012/11902053
<p>The Dose Adjustment for Normal Eating (DAFNE) course is a
structured education programme for adults with Type 1 diabetes. DAFNE has been found to improve glycosylated
haemoglobin (HbA1c) levels in UK Type 1 diabetes patients1 and a
cost-effectiveness modelling analysis concluded that DAFNE was
cost-effective2. This analysis assumed
that HbA1c benefit experienced by patients receiving DAFNE was homogeneous,
however it has been found that HbA1c response to DAFNE is highly variable
between patients. Although some patients do experience significant HbA1c
reductions after DAFNE, other patients experience a worsening of HbA1c1,3 and
some find it difficult to maintain initial HbA1c improvements4. Offering an early ‘follow-up’ intervention to
those patients predicted from their initial change in psychosocial
characteristics not to respond to DAFNE in the long term may be cost-effective
if additional HbA1c benefit can be gained.</p>
<p> </p>
<p>This study aims to explore statistical modelling
methodologies to predict individual clinical responses to DAFNE from
psychosocial characteristics and incorporate psychosocial predictors into an
economic simulation model to investigate the cost-effectiveness of providing a
follow-up intervention to subgroups of predicted non-responders.</p>
2020-02-27 00:07:25
DAFNE
diabetes
non-responders
Health Economics