%0 Conference Paper
%A Tosh, Jonathan
%A Stevenson, Matthew
%A Akehurst, Ronald
%A Strong, Mark
%D 2020
%T A Framework for the Economic Evaluation of Sequential Therapies for Chronic Conditions (2014)
%U https://orda.shef.ac.uk/articles/poster/A_Framework_for_the_Economic_Evaluation_of_Sequential_Therapies_for_Chronic_Conditions_2014_/11914221
%R 10.15131/shef.data.11914221.v1
%2 https://orda.shef.ac.uk/ndownloader/files/21851082
%K sequential therapies
%K chronic conditions
%K economic evaluation
%K Health Economics
%X
Background:
Cost-effectiveness models often evaluate a sequence of treatments
Downstream implications of a sequence should be captured Compare sequences within standard economic evaluation framework
Problem:
For conditions such as rheumatoid arthritis, an optimal treatment sequence has not been identified[1]
Large number of sequences requires excessively large computational time (estimate cost and QALYs estimated for every sequence)
Computation time increases when using individual patient simulation
Evidence for a fully sequential model is not likely to be available
Model
%I The University of Sheffield