%0 Conference Paper %A Tosh, Jonathan %A Stevenson, Matthew %A Akehurst, Ronald %A Strong, Mark %D 2020 %T A Framework for the Economic Evaluation of Sequential Therapies for Chronic Conditions (2014) %U https://orda.shef.ac.uk/articles/poster/A_Framework_for_the_Economic_Evaluation_of_Sequential_Therapies_for_Chronic_Conditions_2014_/11914221 %R 10.15131/shef.data.11914221.v1 %2 https://orda.shef.ac.uk/ndownloader/files/21851082 %K sequential therapies %K chronic conditions %K economic evaluation %K Health Economics %X
Background:
Cost-effectiveness models often evaluate a sequence of treatments
Downstream implications of a sequence should be captured Compare sequences within standard economic evaluation framework

Problem:
For conditions such as rheumatoid arthritis, an optimal treatment sequence has not been identified[1]
Large number of sequences requires excessively large computational time (estimate cost and QALYs estimated for every sequence)
Computation time increases when using individual patient simulation
Evidence for a fully sequential model is not likely to be available
Model
%I The University of Sheffield