10.15131/shef.data.11956143.v1 Jean Sanderson Jean Sanderson Marrissa Martyn-St James Marrissa Martyn-St James Sarah Davies Sarah Davies John Stevens John Stevens Edward Goka Edward Goka Susie Sadler Susie Sadler Clinical effectiveness of bisphosphonates for prevention of fragility fractures: a systematic review and network meta-analysis The University of Sheffield 2020 Clinical effectiveness bisphosphonates fragility fractures systematic review network meta-analysis NIHR osteoporosis NMA alendronate risedronate Ibandronate zoledronate Health Economics 2020-03-09 16:20:37 Poster https://orda.shef.ac.uk/articles/poster/Clinical_effectiveness_of_bisphosphonates_for_prevention_of_fragility_fractures_a_systematic_review_and_network_meta-analysis/11956143 BACKGROUND Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, with a consequent increase in susceptibility to fragility fracture. Fractures cause significant pain, disability and loss of independence and can be fatal. [1] OBJECTIVE To assess the relative efficacy of bisphosphonates (alendronate, risedronate, ibandronate and zoledronate) for the treatment of Osteoporosis using a network meta-analysis (NMA).