10.15131/shef.data.12006384.v1
Susan Harnan
Susan
Harnan
Munira Essat
Munira
Essat
Tim Gomersall
Tim
Gomersall
Paul Tappenden
Paul
Tappenden
Ruth Wong
Ruth
Wong
R. Lawson
R.
Lawson
Ian Pavord
Ian
Pavord
M. Everard
M.
Everard
Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review
The University of Sheffield
2020
Exhaled nitric oxide
asthma
adults
systematic review
Health Economics
2020-03-20 13:26:03
Poster
https://orda.shef.ac.uk/articles/poster/Exhaled_nitric_oxide_for_the_diagnosis_of_asthma_in_children_and_adults_a_systematic_review/12006384
The fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation, which is associated with some forms of asthma. Asthma is currently diagnosed using a pathway of tests including spirometery, airway reversability (response to bronchodilator or course of inhaled corticosteroids (ICS)) and airway hyper-responsiveness (e.g. methocholine challenge). FeNO may be a useful diagnostic test in this pathway. This systematic review aimed to identify and synthsise evidence rating to the diagnostic accuracy of FeNO for asthma with a UK focus. We looked at the highest sum of sensitivity and specificity, as well as evidence about the potential for FeNO to be used as a rule-in test (high-specificity) or as a rule-out test (high-sensitivity).<br>