10.15131/shef.data.12006384.v1 Susan Harnan Susan Harnan Munira Essat Munira Essat Tim Gomersall Tim Gomersall Paul Tappenden Paul Tappenden Ruth Wong Ruth Wong R. Lawson R. Lawson Ian Pavord Ian Pavord M. Everard M. Everard Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review The University of Sheffield 2020 Exhaled nitric oxide asthma adults systematic review Health Economics 2020-03-20 13:26:03 Poster https://orda.shef.ac.uk/articles/poster/Exhaled_nitric_oxide_for_the_diagnosis_of_asthma_in_children_and_adults_a_systematic_review/12006384 The fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation, which is associated with some forms of asthma. Asthma is currently diagnosed using a pathway of tests including spirometery, airway reversability (response to bronchodilator or course of inhaled corticosteroids (ICS)) and airway hyper-responsiveness (e.g. methocholine challenge). FeNO may be a useful diagnostic test in this pathway. This systematic review aimed to identify and synthsise evidence rating to the diagnostic accuracy of FeNO for asthma with a UK focus. We looked at the highest sum of sensitivity and specificity, as well as evidence about the potential for FeNO to be used as a rule-in test (high-specificity) or as a rule-out test (high-sensitivity).<br>