Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review Susan Harnan Munira Essat Tim Gomersall Paul Tappenden Ruth Wong R. Lawson Ian Pavord M. Everard 10.15131/shef.data.12006384.v1 https://orda.shef.ac.uk/articles/poster/Exhaled_nitric_oxide_for_the_diagnosis_of_asthma_in_children_and_adults_a_systematic_review/12006384 The fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation, which is associated with some forms of asthma. Asthma is currently diagnosed using a pathway of tests including spirometery, airway reversability (response to bronchodilator or course of inhaled corticosteroids (ICS)) and airway hyper-responsiveness (e.g. methocholine challenge). FeNO may be a useful diagnostic test in this pathway. This systematic review aimed to identify and synthsise evidence rating to the diagnostic accuracy of FeNO for asthma with a UK focus. We looked at the highest sum of sensitivity and specificity, as well as evidence about the potential for FeNO to be used as a rule-in test (high-specificity) or as a rule-out test (high-sensitivity).<br> 2020-03-20 13:26:03 Exhaled nitric oxide asthma adults systematic review Health Economics