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Clinical effectiveness of bisphosphonates for prevention of fragility fractures: a systematic review and network meta-analysis

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posted on 2020-03-09, 16:20 authored by Jean SandersonJean Sanderson, Marrissa Martyn-St James, Sarah DaviesSarah Davies, John Stevens, Edward Goka, Susie Sadler
BACKGROUND Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, with a consequent increase in susceptibility to fragility fracture. Fractures cause significant pain, disability and loss of independence and can be fatal. [1] OBJECTIVE To assess the relative efficacy of bisphosphonates (alendronate, risedronate, ibandronate and zoledronate) for the treatment of Osteoporosis using a network meta-analysis (NMA).

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    Clinical effectivenessbisphosphonatesfragility fracturessystematic reviewnetwork meta-analysisNIHRosteoporosisNMAalendronaterisedronateIbandronatezoledronateHealth Economics

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