Estimating EQ-5D health states values for Rheumatoid Arthritis patients: a limited dependent variable, mixture modelling approach (2012)

2020-02-28T11:48:19Z (GMT) by MÓNICA HERNÁNDEZ ALAVA Allan Wailoo

• Clinical trials often do not contain preference based outcome measure

• Cost per QALY evaluation requires such outcomes

• Linking clinical to preference based outcomes via statistical model is commonplace in economic evaluation

• 22% of NICE appraisals include “mapping”, 100% in RA

• Typically done using simple regression techniques

• EQ-5D has an odd distribution

• Standard methods perform badly

• Develop and refine a new method here