The role of biochemical markers in the identification of intracranial pathology following minor head injury: a systematic review and meta-analysis

INTRODUCTION Biochemical markers may have a role to play as objective tools for ruling out significant complications following minor head injury, whilst reducing the rate of ‘’unnecessary’’ Computed Tomography (CT) scans. This study aimed to systematically identify and synthesize data estimating the diagnostic accuracy of biochemical markers for intracranial injury on CT in patients with minor head injury (MHI).