VPH-DARE@IT Biomedical Research Platform - Architectural Framework Design and Interoperability

<div>The “Virtual Physiological Human: Dementia Research Enabled by IT” (VPH-DARE@IT) project aims to provide a systematic, multifactorial and multiscale modelling approach to enable improved diagnoses and prognoses of dementias. Whilst several tools are available for isolated tasks in the analysis of brain or brain-related data, a widely accepted solution to collect and harmonise, analyse, and organise data for the modelling of dementias is not yet available. The lack of such tools has been identified as a major challenge with high impact. The VPH-DARE@IT research platform aims to integrate the efforts of project partners and also of other open-source tools, which are already available and focus on</div><div>dementia research, with the goal of providing a single framework where relevant anatomic-physiological representations (e.g. biomarkers & measures) are generated or co-ordinated to create more objective and predictive models of patients’ medical condition progression. The specific objectives of the research platform are to:</div><div><br></div><div> Develop a workflow-oriented and extensible framework for clinical researchers in</div><div>dementia;</div><div> Develop a workflow-oriented and extensible framework for VPH modelling</div><div>researchers in dementia;</div><div> Define and implement automated pipelines for data processing in VPH-DARE@IT; </div><div> Define interoperability mechanisms for integrating the multi-faceted contributions of</div><div>project partners into a single point of service;</div><div> Re-use these interoperability mechanisms for leveraging functionality from other</div><div>open source frameworks in dementia research;</div><div> Support the interaction and integration of such frameworks with the VPH-Share data</div><div>sharing infrastructure;</div><div> Support data-provision centres in VPH-DARE@IT to federate their databases through</div><div>the VPH-Share infrastructure.</div><div><br></div><div>This deliverable aims to describe the architecture of the VPH-DARE@IT research platform, including its relationship with the other main software product of the project – the clinical platform. The approach taken for this document follows the <a href="https://doi.org/10.1109/IEEESTD.2011.6129467">ISO/IEC 42010-2011 standard “System and software engineering – Architecture description”</a> as a guideline for its structure and contents. </div><div><br></div>