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Data for the paper: "Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications"

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posted on 03.11.2020, 12:45 by Enrico Dall'Ara, Sara Oliviero, Gwendolen Reilly, Ilaria Bellantuono, Robert Owen
Data used in the paper: "Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications"
Oliviero, Owen, Reilly, Bellantuono, Dall'Ara
published in JMBBM

We share here an example of ex vivo microCT image used for the assessment, and the results obtained from the different analyses.

Short description of the files included:


Densitometric_and_morphometric_parameters.xlsx includes:

-Densitometric parameters, and correlations with experimental mechanical data, calculated for each specimen and each region of interest

Total = total volume of interest (80% of tibia length)

10 Longitudinal sections: section 1 corresponds to proximal tibia, section 10 corresponds to distal tibia

Sectors: anterior (A), posterior (P), medial (M) and lateral (L)


-Morphometric parameters calculated for each specimen, and correlations with experimental mechanical data.

-microFE_results.xlsx includes:

Stiffness estimated for each specimen with microFE models, and correlations with experimental data.

Failure load estimated with microFE models, and correlations with experimental data, for each failure criterion:

Pistoia method

Compression: tibia fails when a portion of the nodes (failure volume) reaches a critical compressive (third principal) strain level

Tension: tibia fails when a portion of the nodes reaches a critical tensile (first principal) strain level

Compression&Tension: tibia fails when a portion of the nodes reaches a critical strain, either in tension or in compression

Sections: tibia fails when the median first principal strain or third principal strain in one section (tibia divided into ten portions) or in one sector (tibia divided into ten sections and each section divided into anterior and posterior partitions; 20 portions in total) reaches a critical strain level

-microCT data:

Example of a segmented microCT image used as input for the microFE model (Specimen1, C57BL/6J, wild type, 16 weeks of age, right tibia).



In case the reader is interested in the whole database they should contact Dr Enrico Dall'Ara (e.dallara@sheffield.ac.uk).

Funding

The study was partially funded by the UK National Centre for the Replacement, Refinement and 4 Reduction of Animals in Research (NC3Rs, Grant number: NC/R001073/1) and by the Engineering 5 and Physical Sciences Research Council (EPSRC) Frontier Multisim Grant (EP/K03877X/1 and 6 EP/S032940/1). RO was funded by an EPSRC Doctoral Prize Fellowship (EP/N509735/1).

History

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There is no personal data or any that requires ethical approval

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The data complies with the institution and funders' policies on access and sharing

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The data can be shared openly

Data description

  • The file formats are open or commonly used

Methodology, headings and units

  • Headings and units are explained in the files

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