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Data relating to the publication "Expression and regulation of drug transporters in vertebrate neutrophils".

dataset
posted on 23.06.2017, 11:52 by Matthew Foulkes, Katherine Henry, Julien Rougeot, Edward Hooper-Greenhill, Catherine Loynes, Phil Jeffrey, Angeleen Fleming, Caroline O. Savage, Annemarie H. Meijer, Simon Jones, Stephen Renshaw
Data relating to the publication Foulkes, M. J. et al. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports, 7, 4967. http://doi.org/10.1038/s41598-017-04785-4

Expression of SLC and ABC transporters in human and zebrafish neutrophils.

Protein sequences for both human and zebrafish transporters can be found in files named: Protein sequences_human and Protein sequences_zebrafish

Expression data can be found in files named:
Expression data_human and Expression data_zebrafish

Methods involved in generating these data are documented in the paper.

Abbreviations:
ABC - ATP-binding cassette
dpf - days post fertilisation
FPKM - fragments per kilobase of exon per million fragments mapped
SLC - solute carrier
UNTR - untreated

Zebrafish lines used:
mpx:GFP i114 neutrophil-specific GFP

Funding

This work was supported by a Medical Research Council (MRC) Senior Clinical Fellowship with Fellowship-Partnership Award and an MRC Programme Grant to S.A.R. (G0701932 and MR/M004864/1) and MRC Centre Grant G0700091. J.R. and A.H.M. were supported by the European Commission FP7 Initial Training Network FishForPharma (PITG-GA-2011-289209).

History

Ethics

There is no personal data or any that requires ethical approval

Policy

The data complies with the institution and funders' policies on access and sharing

Sharing and access restrictions

The data can be shared openly

Data description

  • The file formats are open or commonly used

Methodology, headings and units

  • Headings and units are explained in the files

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