Data relating to the publication "Expression and regulation of drug transporters in vertebrate neutrophils".
dataset
posted on 2017-06-23, 11:52 authored by Matthew Foulkes, Katherine Henry, Julien Rougeot, Edward Hooper-Greenhill, Catherine LoynesCatherine Loynes, Phil Jeffrey, Angeleen Fleming, Caroline O. Savage, Annemarie H. Meijer, Simon Jones, Stephen RenshawStephen RenshawData relating to the publication Foulkes, M. J. et al. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports, 7, 4967. http://doi.org/10.1038/s41598-017-04785-4
Protein sequences for both human and zebrafish transporters can be found in files named: Protein sequences_human and Protein sequences_zebrafish
Expression data can be found in files named:
Expression data_human and Expression data_zebrafish
Methods involved in generating these data are documented in the paper.
Abbreviations:
ABC - ATP-binding cassette
dpf - days post fertilisation
FPKM - fragments per kilobase of exon per million fragments mapped
SLC - solute carrier
UNTR - untreated
Zebrafish lines used:
mpx:GFP i114 neutrophil-specific GFP
Funding
This work was supported by a Medical Research Council (MRC) Senior Clinical Fellowship with Fellowship-Partnership Award and an MRC Programme Grant to S.A.R. (G0701932 and MR/M004864/1) and MRC Centre Grant G0700091. J.R. and A.H.M. were supported by the European Commission FP7 Initial Training Network FishForPharma (PITG-GA-2011-289209).
History
References
Ethics
There is no personal data or any that requires ethical approvalPolicy
The data complies with the institution and funders' policies on access and sharingSharing and access restrictions
The data can be shared openlyData description
- The file formats are open or commonly used
Methodology, headings and units
- Headings and units are explained in the files
CC BY 4.0