Magnetic resonance imaging (MRI) 2010 HARNAN.pdf (114.31 kB)
Download fileMagnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review
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posted on 2020-02-25, 10:02 authored by Susan HarnanSusan Harnan, Katy Cooper, Yang Meng, Susan Ward, P. Fitzgerald, Diana PapaioannouDiana Papaioannou, Lynda WyldLynda Wyld, C. Ingram, I. Wilkinson, E. LorenzINTRODUCTION
Assessment of axillary lymph node status is important in breast cancer staging. UK guidance
recommends sentinel lymph node biopsy (SLNB) or 4-node sampling (4-NS) where ultrasound and
ultrasound-guided biopsy are negative. Where biopsy, SLNB or 4-NS are positive, axillary lymph node
dissection (ALND) is recommended. The surgical procedure ALND, and to a lesser extent SLNB and
4-NS, are associated with adverse effects such as arm lymphoedema. Magnetic resonance imaging
(MRI) provides detailed images of the body in any plane and is a non-invasive technique with few
adverse events. An MRI scan may provide information on whether a lymph node is suspicious for
metastasis, avoiding the need for surgery and its associated adverse effects. However, it is unclear
whether MRI can match the excellent diagnostic accuracies of ALND, SLNB and 4-NS.
OBJECTIVE
To assess the diagnostic accuracy and effect on patient outcomes of MRI for assessment of axillary
lymph nodes in newly diagnosed early breast cancer.
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